Transcriptomics

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RNA polyadenylation landscape in human and mouse cells


ABSTRACT: Alternative polyadenylation (APA) of mRNAs has emerged as an important mechanism for post-transcriptional gene regulation in higher eukaryotes. Although microarrays have recently been used to characterize APA globally, they have a number of serious limitations that prevents comprehensive and highly quantitative analysis. To better characterize APA and its regulation, we have developed a deep sequencing-based method called Poly(A) Site Sequencing (PAS-Seq) for quantitatively profiling RNA polyadenylation at the transcriptome level. PAS-Seq not only accurately and comprehensively identifies poly(A) junctions in mRNAs and noncoding RNAs, but also provides quantitative information on the relative abundance of polyadenylated RNAs.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE25450 | GEO | 2011/02/26

SECONDARY ACCESSION(S): PRJNA133813

REPOSITORIES: GEO

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