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Gene expression of three prostate lobes, ventral prostate (VP), dorsal lateral prostate (DLP), and anterior prostate (AP), by cholesterol diet

ABSTRACT: Understanding the systemic regulation of normal prostate gene expression by cholesterol diet is critical for deciphering the mechanisms responsible for the transition from healthy to pathogenic prostate conditions. To understand mechanism under cholesterol effect on prostate, we performed microarray analysis using prostate tissues from SCID or C57BL/6 mice feed with varying diet conditions containing high, low or normal cholesterol.

ORGANISM(S): Mus musculus

PROVIDER: GSE25461 | GEO | 2011/12/01

SECONDARY ACCESSION(S): PRJNA142583

REPOSITORIES: GEO

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Gene expression of three prostate lobes, ventral prostate (VP), dorsal lateral prostate (DLP), and anterior prostate (AP), by cholesterol diet

Project description:Understanding the systemic regulation of normal prostate gene expression by cholesterol diet is critical for deciphering the mechanisms responsible for the transition from healthy to pathogenic prostate conditions. To understand mechanism under cholesterol effect on prostate, we performed microarray analysis using prostate tissues from SCID or C57BL/6 mice feed with varying diet conditions containing high, low or normal cholesterol. The RNA is obtained from ventral prostate (VP), dorsal lateral prostate (DLP), and anterior prostate (AP) in 18 SCID mice.

2011-12-01 | E-GEOD-25461 | biostudies-arrayexpress

The Response of the Prostate to Changes in Circulating Cholesterol: Activating Transcription Factor 3 (ATF3) as a Cholesterol Sensor

Project description:This SuperSeries is composed of the following subset Series: GSE25461: Gene expression of three prostate lobes, ventral prostate (VP), dorsal lateral prostate (DLP), and anterior prostate (AP), by cholesterol diet GSE25472: Gene expression of LNCaP human prostate cells by cholesterol diet Refer to individual Series

2011-12-01 | E-GEOD-25500 | biostudies-arrayexpress

Gene expression of LNCaP human prostate cells by cholesterol diet

Project description:Understanding the systemic regulation of normal prostate gene expression by cholesterol diet is critical for deciphering the mechanisms responsible for the transition from healthy to pathogenic prostate conditions. To understand mechanism under cholesterol effect on prostate, we performed microarray analysis using LNCaP human prostate cells cultured in low cholesterol medium. The RNA is obtained from LNCaP human prostate cells serum-starved for 0h, 3h, 16h followed by CLM medium.

2011-12-01 | E-GEOD-25472 | biostudies-arrayexpress

Gene expression of LNCaP human prostate cells by cholesterol diet

2011-12-01 | GSE25472 | GEO

High Fat Diet Reduces the Expression of Glutathione Peroxidase 3 in Mouse Prostate

Project description:High fat diets are known to be a risk factor for prostate cancer. In this study, we investigated the effect of high fat diet on mouse prostate gene expression. C57BL/6J mice were fed either a control or high fat diet for 12 weeks. Microarray analyses were performed on mouse ventral prostate (VP) and dorsolateral prostate (DLP), followed by canonical pathway analysis and regulatory network identification. mRNA changes were confirmed by real time PCR. Approximately 2,125, and 1,194 genes responded significantly to the high fat diet in VP, DLP, respectively. Pathways and networks related to oxidative stress, glutathione metabolism, NRF-mediated oxidative stress response and NF-kappaB were all differentially regulated by high fat diet. GPx3 mRNA levels were decreased by approximately 2-fold by high fat diet in all 3 prostate lobes. In human non-transformed prostate cells (PrSC, PrEC and BPH-1), cholesterol loading decreased GPx3 expression, and increased H2O2 levels of culture medium. Troglitazone increased GPx3 expression in 3 normal prostate cells, and decreased H2O2 levels. In addition, troglitazone attenuated cholesterol-induced H2O2 increase. Tissue from prostate cancer biopsies had decreased GPx3 mRNA and its level was inversely related to the Gleason score. High fat diet alters pathways related to many genes concerned with oxidative stress. GPx3, a gene identified by this analysis, was found to be down regulated by high fat diet and appears be decreased in human prostate cancers, suggesting that GPx3 may have a possible role in modulating carcinogenesis. Control group:5 C57BL/6J mice (Taconic, Hudson, NY), 8-weeks of age, fed control diet ad libitum for 12 weeks; Experimental group: 5 C57BL/6J mice (Taconic, Hudson, NY), 8-weeks of age, fed ad libitum high fat diet for 12 weeks.

2012-01-02 | E-GEOD-26464 | biostudies-arrayexpress

The miRNA profile from rats ventral prostate submitted to maternal low protein diet

Project description:Purpose: The goals of this study are to compare NGS-derived ventral prostate transcriptome profiling (RNA-seq) from control and offspring submitted to maternal low protein diet during gestation and lactational period, on postnatal day 21 and 540. Methods: Ventral prostate microRNA profiles of 21- and 540-day-old control rats (CTR) and gestacional and lactacional low protein diet rats (GLLP) were generated by deep sequencing, in triplicate, using Illumina HiSeq-2500.

2021-07-25 | GSE180674 | GEO

The mRNA profile from rats ventral prostate submitted to maternal low protein diet

Project description:Purpose: The goals of this study are to compare NGS-derived ventral prostate transcriptome profiling (RNA-seq) from control and offspring submitted to maternal low protein diet during gestation and lactational period, on postnatal day 21 and 540. Methods: Ventral Prostate mRNA profiles of 21- and 540-day-old control rats (CTR) and gestational and lactational low protein diet rats (GLLP) were generated by deep sequencing, in triplicate, using Illumina HiSeq-2500.

2021-07-25 | GSE180673 | GEO

High Fat Diet Reduces the Expression of Glutathione Peroxidase 3 in Mouse Prostate

2012-01-02 | GSE26464 | GEO

Social cognition and the anterior temporal lobes.

Project description:Two distinct literatures have emerged on the functionality of the anterior temporal lobes (ATL): in one field, the ATLs are conceived of as a repository for semantic or conceptual knowledge. In another field, the ATLs are thought to play some undetermined role in social-emotional functions such as Theory of Mind. Here we attempted to reconcile these distinct functions by assessing whether social semantic processing can explain ATL activation in other social cognitive tasks. Social semantic functions refer to knowledge about social concepts and rules. In a first experiment we tested the idea that social semantic representations can account for activations in the ATL to social attribution stimuli such as Heider and Simmel animations. Left ATL activations to Heider and Simmel stimuli overlapped with activations to social words. In a second experiment we assessed the putative roles of the ATLs in the processing of narratives and theory of mind content and found evidence for a role of the ATLs in the processing of theory of mind but not narrative per se. These findings indicate that the ATLs are part of a neuronal network supporting social cognition and that they are engaged when tasks demand access to social conceptual knowledge.

| S-EPMC2818559 | biostudies-literature

Transgenic expression of miR-32 in mouse ventral prostate

Project description:Transcriptional profiling of ventral prostate of mice with prostate-specific transgenic expression of miR-32 compared with wild type mice.

2017-06-27 | GSE100475 | GEO

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