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Disruption of RNAPII transcription elongation links Oncogenic splicing factor mutations to replciation stress and targetable alterations in chromatin landscape [Ser5PRNAPII ChIP-Seq]

ABSTRACT: To investigate changes in the elongating form of RNA Polymerase II across different conditions, we peformed ChIP-seq using antibody against the Ser5P RNAPII of pTEFb in K562 cells at 4 days after modified allele expression We then performed coverage plot analyses using data obtained from ChIP-seq from IP and Input fractions to investigate Ser5P RNAPII distribution changes

ORGANISM(S): Homo sapiens

PROVIDER: GSE254791 | GEO | 2024/03/12

REPOSITORIES: GEO

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