Single-cell transcriptomic analysis Treg cells in peripheral lymph nodes
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ABSTRACT: Treg cell-specific ablation of Cxxc1 leads to the development of a lethal inflammatory disease characterized by spontaneous T-cell activation.Cxxc1-deficient Treg cells showed reduced immunosuppressive capacity without affecting Treg cell numbers.To investigate the role of Cxxc1 as a transcriptional regulator of Treg subsets, we performed single-cell RNA-seq (scRNA-seq) paired with T cell receptor sequencing (TCR-seq) .
ORGANISM(S): Mus musculus
PROVIDER: GSE254883 | GEO | 2025/03/29
REPOSITORIES: GEO
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