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MicroRNA profiling of mesenchymal stem cells from adipose tissue of differentially aged mice

ABSTRACT: The data presented here is part of a study aimed to investigate whether the gene expression profile of Polycomb, Trithorax and interacting molecules might be related to different states of differentiative potential.

ORGANISM(S): Mus musculus

PROVIDER: GSE25679 | GEO | 2010/11/30

SECONDARY ACCESSION(S): PRJNA142443

REPOSITORIES: GEO

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microRNA profiling of mesenchymal stem cells from adipose tissue of differentially aged mice

Project description:The data presented here is part of a study aimed to investigate whether the gene expression profile of Polycomb, Trithorax and interacting molecules might be related to different states of differentiative potential. microRNA profiling (Exiqon miRCURY LNA array Version 9.2) has been performed on mesenchymal stem cells isolated from the inguinal fat pad of mice of 1 (n=2), 3(n=2), 6(n=2), 12(n=2) and 24(n=1) months of age.

2010-11-30 | E-GEOD-25679 | biostudies-arrayexpress

PcG/TrxG profiling of differentially aged adipose-derived mesenchymal stem cells

Project description:The microarray reported here is part of a study aimed to investigate whether the gene expression profile of Polycomb, Trithorax and interacting molecules (collectively referred to PcG/TrxG genes) might be related to different states of differentiative potential. In particular , this microarray profiles the expression of PcG/TrxG genes in adipose-derived mesenchymal stem cells isolated from the inguinal fat depot of mice of different age. MSC have been isolated from the inguinal fat pad of FVB mice aged 1, 3, 6, 12 or 24 months.

2010-11-30 | E-GEOD-25068 | biostudies-arrayexpress

PcG/TrxG profiling of differentially aged adipose-derived mesenchymal stem cells

2010-11-30 | GSE25068 | GEO

Whole-genome microarray of long-term cultured adipose derived mesenchymal stem cells from differentially-aged mice

Project description:The microarray reported here is part of a study aimed to investigate whether the gene expression of Polycomb, Trithorax and interacting molecule might be related to differet states of differentialtive potential. In particular, the dataset herein is a whole-genome microarray profiling of long-term (20th passage) cultured mesenchymal stem cells isolated from the inguinal fat pad of mice of differentially aged mice. Whole genome transcriptional profile of mesenchymal stem cells isolated from FVB mice of 1 (n=3) or 12 (n=3) months of age.

2010-11-30 | E-GEOD-25069 | biostudies-arrayexpress

Profiling of mesenchymal stem cells from adipose tissue of differentially aged mice

Project description:This SuperSeries is composed of the following subset Series: GSE25068: PcG/TrxG profiling of differentially aged adipose-derived mesenchymal stem cells GSE25069: Whole-genome microarray of long-term cultured adipose derived mesenchymal stem cells from differentially-aged mice GSE25679: microRNA profiling of mesenchymal stem cells from adipose tissue of differentially aged mice Refer to individual Series

2010-11-30 | E-GEOD-25685 | biostudies-arrayexpress

Profiling of mesenchymal stem cells from adipose tissue of differentially aged mice

Project description:This SuperSeries is composed of the SubSeries listed below.

2010-11-30 | GSE25685 | GEO

Genome-wide binding of WDR5 and GRHL3

2012-11-10 | GSE42180 | GEO

Whole-genome microarray of adipose derived mesenchymal stem cells from differentially-aged mice

Project description:whole-genome microarray profiling of mesenchymal stem cells isolated from the inguinal fat pad of mice of different age.

2010-11-30 | GSE25069 | GEO

Genome-wide binding of WDR5 and GRHL3

Project description:The antagonistic actions of Polycomb and Trithorax are responsible for proper cell fate determination in mammalian tissues. In the epidermis, a self-renewing epithelium, previous work has shown that release from Polycomb repression only partially explains differentiation gene activation. We now show that Trithorax is also a key regulator of epidermal differentiation, not only through activation of genes repressed by Polycomb in progenitor cells, but also through activation of genes independent of regulation by Polycomb. The differentiation associated transcription factor GRHL3/GET1 recruits the ubiquitously expressed Trithorax complex to a subset of differentiation genes. Examination of WDR5 and GRHL3 binding in human differentited primary keratinocytes (NHEK). High calcium medium was added to NHEK cells at 50% confluency to induce differentiation. Cells were collected for ChIP 24 hours after addition of high calcium medium. ChIP with Wdr5 and Grhl3 antibodies, and an input control were sequenced.

2012-11-10 | E-GEOD-42180 | biostudies-arrayexpress

PRC2 is required for acute myeloid leukemias initiated by MLL-AF9

Project description:The transcriptional activating and repressive functions performed by Trithorax and Polycomb group complexes, respectively, are critical for to maintain cellular fates in ontogeny and in cancer. Here we report that leukemias initiated by a Trithorax-related oncogene, MLL-AF9, depend upon the Polycomb Repressive Complex 2 (PRC2) to sustain a transformed cellular state. RNAi mediated suppression of PRC2 subunits is sufficient to inhibit proliferation of MLL-AF9 leukemias, with little impact on growth of non-transformed cells. This requirement is partly due to PRC2-mediated transcriptional repression of several anti-self-renewal regulators, including Cdkn2a. These results suggest that, unlike the classical antagonism generally observed between Polycomb and Trithorax group proteins during development, the activities of these two pathways can cooperate to promote myeloid neoplasia.

2013-07-01 | GSE34183 | GEO

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