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Cellular dynamics of pig-to-human kdiney xenotransplantation [RNA-seq]

ABSTRACT: We performed comprehensive single-cell RNA sequencing (scRNA-seq) analyses of the two porcine xenografts and their contralateral untransplanted kidneys to dissect xenotransplantation-associated cellular dynamics and xenograft-recipient interactions. We additionally performed longitudinal bulk RNA-seq on core biopsies to dissect the time-resolved physiological changes of the xenografts and longitudinal scRNA-seq of peripheral blood mononuclear cells (PBMCs) to detect recipient’s immune responses across time.

ORGANISM(S): Sus scrofa

PROVIDER: GSE257541 | GEO | 2024/06/30

REPOSITORIES: GEO

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Cellular dynamics of pig-to-human kdiney xenotransplantation [single cell RNA-seq]

Project description:We performed comprehensive single-cell RNA sequencing (scRNA-seq) analyses of the two porcine xenografts and their contralateral untransplanted kidneys to dissect xenotransplantation-associated cellular dynamics and xenograft-recipient interactions. We additionally performed longitudinal bulk RNA-seq on core biopsies to dissect the time-resolved physiological changes of the xenografts and longitudinal scRNA-seq of peripheral blood mononuclear cells (PBMCs) to detect recipient’s immune responses across time.

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Cellular dynamics of pig-to-human kdiney xenotransplantation [RNA-seq]

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Cellular dynamics of pig-to-human kdiney xenotransplantation [single cell RNA-seq]

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