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Pooled screening for CAR function in glioblastoma

ABSTRACT: Human primary CD3+ T cells expressing IL13Ra2-targeted chimeric antigen receptors (CARs) that had been identified through high throughput pooled screening were rechallenged with an IL13Ra2+ human glioblastoma cell line , then stained with CITESEQ antibodies indicative of T cell memory and exhaustion state and prepared for single cell sequencing in order to determine their phenotypic responses to chronic tumor challenge relative to that of a clinical standard CAR.

ORGANISM(S): Homo sapiens

PROVIDER: GSE259352 | GEO | 2024/04/19

REPOSITORIES: GEO

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