Telomerase is essential for cardiac differentiation and sustained metabolism of human cardiomyocytes II
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ABSTRACT: In this study, we employed an inducible CRISPRi human induced pluripotent stem cell (hiPSC) line to silence TERT expression enabling the generation of hiPSCs and hiPSC-derived cardiomyocytes with long and short telomeres. Reduced telomerase activity and shorter telomere lengths of hiPSCs strongly hampered their differentiation potential towards cardiomyocytes
ORGANISM(S): Homo sapiens
PROVIDER: GSE260618 | GEO | 2024/04/25
REPOSITORIES: GEO
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