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Lag3 and PD-1 pathways regulate NFAT-dependent TCR signalling programmes during early CD4+ T cell activation

ABSTRACT: Here we perform QuantSeq 3' mRNA sequencing of RNA extracted from flow sorted splenic CD4+ T cell from Tg4 Nr4a3-Tocky Tiger mice that been reactivated in the presence of Isotype, anti-PD-L1, anti-Lag3 or combination therapy. Transcriptional analysis reveals strong T cell receptor signalling, T helper cell bias and metabolic priming in response to combination therapy.

ORGANISM(S): Mus musculus

PROVIDER: GSE260895 | GEO | 2025/03/03

REPOSITORIES: GEO

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