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Molecular differences between neonatal and adult stria vascularis from organotypic explants and transcriptomics

ABSTRACT: The stria vascularis (SV) generates the endocochlear potential that is required for hearing and maintains the blood-labyrinth barrier which protects the inner ear from pathogenic infiltration. SV degeneration disrupts cochlear homeostasis and results in progressive and irreversible hearing loss, yet little is known about this tissue. We elucidate the molecular differences between the neonatal (post-natal day 1, P1) and adult (P30) SV through the analysis of single-cell RNA sequencing on SV from both stages. We revealed key genes, transcription factors, and pathways unique to each stage that may play a role in SV proliferation, development, and maintenance.

ORGANISM(S): Mus musculus

PROVIDER: GSE262019 | GEO | 2025/01/27

REPOSITORIES: GEO

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