Transcriptomics

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A Pathobiological Role of the Insulin Receptor in CLL.


ABSTRACT: Purpose: The chromosomal deletion 11q affects biology and clinical outcome in CLL but del11q-deregulated genes remain incompletely characterized. Results: We have identified differential expression of the insulin receptor (INSR) in CLL, including high-level INSR expression in the majority of CLL with del11q. High INSR mRNA expression in 11q CLL (~10-fold higher mean levels than other genomic categories) was confirmed by Q-PCR in 247 CLL cases. INSR protein measurements in 257 CLL cases through FACS, compared with measurements in normal CD19+ B-cells and monocytes, confirmed that a subset of CLL aberrantly expresses high INSR levels.

ORGANISM(S): Homo sapiens

PROVIDER: GSE26526 | GEO | 2011/05/06

SECONDARY ACCESSION(S): PRJNA136641

REPOSITORIES: GEO

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