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Effect of Large Brown Adipocyte-secreted Proteins on Type 1 Diabetic Mice (NOD) Brown Adipose Tissue

ABSTRACT: Brown adipose tissue has been recognized as an important endocrine organ for metabolic health. In our study, we found that large proteins secreted by brown adipocyte (CB-100) promote the recovery of euglycemia in type 1 diabetic mice (NOD) when injected at an early stage of the disease. To further elucidate the in vivo effects of CB-100, we analyzed brown adipose tissue from both CB-100 and sham-treated mice. Differential gene expression analysis revealed that BAT from CB-100-treated NOD mice exhibited higher thermogenic activity. This suggests that the recovery of euglycemia in CB-100-treated mice may be attributed to enhanced thermogenic activity of the brown adipose tissue, which also contributes to glucose clearance

ORGANISM(S): Mus musculus

PROVIDER: GSE265915 | GEO | 2025/03/24

REPOSITORIES: GEO

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Effect of Large Brown Adipocyte-secreted Proteins on Type 1 Diabetic Mice (NOD) inguinal white adipose tissue

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