Transcriptomics

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TEAD4 role in trophectoderm commitment and development is not conserved in non-rodent mammals


ABSTRACT: The first lineage differentiation in mammals gives rise to the inner cell mass (ICM) and the trophectoderm (TE). In mice, TEAD4 is a master regulator of TE commitment, as it regulates the expression of other TE-specific genes and its ablation prevents blastocyst formation, but its role in other mammals remains unclear. TEAD4 ablation in bovine embryos did not impede TE differentiation or blastocyst formation, but a transcriptomic analysis was performed to see if there were any transcriptomic anomalies in knockout embryos.

ORGANISM(S): Bos taurus

PROVIDER: GSE266304 | GEO | 2024/05/05

REPOSITORIES: GEO

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