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Single nuclei ATACseq profiling of Human Pancreatic Islets across sex

ABSTRACT: Mechanisms driving sex differences across islet cells is unknown. Thus, studying sex differences in islet regulation and function represent a unique avenue to understand the sex-specific heterogeneity in β cell failure in diabetes. We examined sex and race differences in human pancreatic islets from 15 donors using an orthogonal series of experiments including single cell RNA-seq (scRNA-seq), single nucleus assay for transposase-accessible chromatin sequencing (snATAC-seq), dynamic hormone secretion, and bioenergetics.

ORGANISM(S): Homo sapiens

PROVIDER: GSE266405 | GEO | 2024/07/25

REPOSITORIES: GEO

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