Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single-cell analyses offer insights into the different remodeling programs of arteries and veins (scRNA-Seq)

ABSTRACT: We compared 3 non-diseased human arteries (brachial) and 3 veins (2 basilic, 1 cephalic) by single cell RNA sequencing and histology.

ORGANISM(S): Homo sapiens

PROVIDER: GSE266682 | GEO | 2024/06/05

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Single-cell analyses offer insights into the different remodeling programs of arteries and veins (bulk RNA-Seq)

Project description:We compared 7 pairs of arteries (brachial) and veins (6 basilic, 1 cephalic) obtained from the same individuals by bulk RNA sequencing and histology. Independent samples were compared by scRNA-seq.

2024-06-05 | GSE266681 | GEO

Microarray analysis of mesenteric arteries and veins in Crohn's disease compared to controls from non-IBD samples

Project description:Histology in the mesentery pointed to altered blood vessels. This experiment was designed to define the differences in gene expression in vessels from Crohn's disease versus controls. Crohn's disease was separately evaluated in inflamed (central disease) areas and in adjacent noninflamed areas. Laser capture microdissection was carried out on Carnoy's fixed mesenteric samples, comparing normal arteries or veins with Crohn's inflamed or nonifnlamed arteries or veins.

2015-03-05 | E-GEOD-66545 | biostudies-arrayexpress

The intricate cellular ecosystem of human peripheral veins as revealed by single-cell transcriptomic analysis

Project description:We applied single-cell RNA sequencing to 4 non-diseased human veins (3 basilic, 1 cephalic) obtained from organ donors, followed by bioinformatic and histological analyses.

2023-12-23 | GSE250469 | GEO

Transcription profiling of human umbilical arteries and veins

Project description:This experiment compares veins with arteries using microarrays.

2008-03-10 | E-TABM-368 | biostudies-arrayexpress

Single-cell analyses offer insights into the different remodeling programs of arteries and veins

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-06-05 | GSE266684 | GEO

Expression data from intracranial arteries and intracranial aneurysms

Project description:Gene expression information is useful in prioritizing candidate genes in linkage intervals. The data can also identify pathways involved in the pathophysiology of disease. We used microarrays to identify which genes are expressed in either intracranial arteries (control) or in intracranial aneurysms (case), and can therefore contribute to the disease phenotypes. We used microarrays to identify the pathway membership of expressed genes and the overrepresentation of pathways with expressed genes in the known linkage intervals for intracranial aneurysms. Keywords: Characterization of expression in both diseased and non-diseased intracranial arteries.

2007-11-20 | GSE6551 | GEO

The proteome of personalized tissue-engineered veins

Project description:Tissue-engineered veins were generated by reconditioning decellularized veins from both human and pig with whole-blood from respective species. Decellularized human vena femoralis from three donor were reconditioned with human whole blood from four donors. In addition, decellularized pig vena cava from three donors were reconditioned with pig whole blood from three different donors. The proteomes of the tissue-engineered veins were investigated applying the TMT-based proteomics to explore differences between species, regarding the gain of biological material by the reconditioning process.

2024-05-21 | PXD044069 | Pride

Extracellular Matrix Analysis of Human Varicose Veins

Project description:To understand the consequences of venous hypertension, normal and varicose veins were evaluated using proteomics approaches targeting the extracellular matrix.

2016-05-03 | PXD002555 | Pride

Arterial vs venous expression of genes: differences in inflammatory genes

Project description:Arteries and veins modulate cardiovascular homeostasis and contribute to the pathogenesis of hypertension. Functional differences between normal arteries and veins are based upon differences in gene expression. To better characterize these expression patterns, and to identify candidate genes that could be manipulated selectively in the venous system, we performed whole genome expression profiling of rat arteries and veins using the CodeLink platform. We used the major artery and vein of the rat, the thoracic aorta and caudal vena cava, respectively. Expression of mRNA for thrombospondins (TSP-1, 2, 4) was greater than 5-fold higher in veins vs arteries. The most prominent gene expression difference between the normal aorta and vena cava was pancreatitis associated protein (PAP1), a protein with anti-inflammatory functions that was 64-fold higher in vena cava vs aorta. Higher mRNA expression of TSP-1, TSP-2, TSP-4 and PAP1 in vena cava vs aorta was confirmed with real time RT-PCR. Importantly, immunohistochemical analysis of blood vessels sections qualitatively confirmed a higher expression of proteins in vena cava vs aorta. These studies report a difference in inflammatory genes in arteries vs veins. A particularly notable finding is the discovery of PAP1 mRNA and protein expression in peripheral blood vessels with a substantially higher expression in the veins. Data from these studies may provide novel insights into the genetic basis for functional differences between arteries and veins in health and disease.

2009-07-13 | GSE12255 | GEO

Arterial vs venous expression of genes: differences in inflammatory genes

2009-07-13 | E-GEOD-12255 | biostudies-arrayexpress