Proteomics

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The proteome of personalized tissue-engineered veins

ABSTRACT: Tissue-engineered veins were generated by reconditioning decellularized veins from both human and pig with whole-blood from respective species. Decellularized human vena femoralis from three donor were reconditioned with human whole blood from four donors. In addition, decellularized pig vena cava from three donors were reconditioned with pig whole blood from three different donors. The proteomes of the tissue-engineered veins were investigated applying the TMT-based proteomics to explore differences between species, regarding the gain of biological material by the reconditioning process.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human) Sus Scrofa Domesticus (domestic Pig)

TISSUE(S): Artery

SUBMITTER: Georgios Mermelekas  

LAB HEAD: Janne Lehtiö

PROVIDER: PXD044069 | Pride | 2024-05-21

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
20190806_GMJSLJ_TMT10_SET1_500ug_IPG3-10_fr01.raw Raw
20190806_GMJSLJ_TMT10_SET1_500ug_IPG3-10_fr02.raw Raw
20190806_GMJSLJ_TMT10_SET1_500ug_IPG3-10_fr03.raw Raw
20190806_GMJSLJ_TMT10_SET1_500ug_IPG3-10_fr04.raw Raw
20190806_GMJSLJ_TMT10_SET1_500ug_IPG3-10_fr05.raw Raw
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Publications

Vascular diseases are the largest cause of death globally and impose a major global burden on healthcare. The gold standard for treating vascular diseases is the transplantation of autologous veins, if applicable. Alternative treatments still suffer from shortcomings, including low patency, lack of growth potential, the need for repeated intervention, and a substantial risk of developing infections. The use of a vascular ECM scaffold reconditioned with the patient's own cells has shown successfu  ...[more]

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