Transcriptomics

Dataset Information

0

Suppression of melanoma by mice lacking MHC-II: mechanisms and implications for cancer immunotherapy


ABSTRACT: Immune checkpoint inhibitors interfere with T cell exhaustion but often fail to cure or control cancer long-term in patients. Using a genetic screen in C57BL/6J mice, we discovered a mutation in host H2-Aa that caused strong immune-mediated resistance to mouse melanomas. H2-Aa encodes an MHC class II α chain, and its absence in C57BL/6J mice eliminates all MHC-II expression. H2-Aa deficiency, specifically in dendritic cells (DC), led to a quantitative increase in type 2 conventional DC (cDC2) and a decrease in cDC1. H2-Aa–deficient cDC2, but not cDC1, were essential for melanoma suppression and effectively cross-primed and recruited CD8 T cells into tumors. Lack of T regulatory cells, also observed in H2-Aa deficiency, contributed to melanoma suppression. Acute disruption of H2-Aa was therapeutic in melanoma-bearing mice, particularly when combined with checkpoint inhibition, which had no therapeutic effect by itself. Our findings suggest that inhibiting MHC-II may be an effective immunotherapeutic approach to enhance immune responses to cancer.

ORGANISM(S): Mus musculus

PROVIDER: GSE266960 | GEO | 2024/10/22

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2020-06-11 | GSE152196 | GEO
2023-03-01 | GSE198651 | GEO
2015-09-17 | GSE73077 | GEO
2020-04-30 | GSE147458 | GEO
2022-07-19 | E-MTAB-11888 | biostudies-arrayexpress
2024-02-01 | GSE241341 | GEO
2024-08-18 | GSE270060 | GEO
2015-08-01 | E-GEOD-68399 | biostudies-arrayexpress
2024-05-29 | GSE262477 | GEO
2024-05-29 | GSE262474 | GEO