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IRF2BP2 affects T-ALL cell proliferation by cooperating with master transcription factors [RNA-Seq]

ABSTRACT: Knocking down IRF2BP2 led to decreased T-cell acute lymphoblastic leukemia (T-ALL) cell survival and growth both in vitro and in vivo. To explore IRF2BP2-dependent gene regulation, RNA-seq analysis was conducted and the differently expressed genes were revealed in the IRF2BP2-knockdown J.gamma1 cells in comparison to control group.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE267261 | GEO | 2024/10/26

REPOSITORIES: GEO

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IRF2BP2 affects T-ALL cell proliferation by cooperating with master transcription factors [Cut&Tag]

Project description:Knocking down IRF2BP2 led to decreased T-cell acute lymphoblastic leukemia (T-ALL) cell survival and growth both in vitro and in vivo. To explore IRF2BP2-dependent gene regulation, RNA-seq analysis was conducted and the differently expressed genes were revealed in the IRF2BP2-knockdown J.gamma1 cells in comparison to control group. Cleavage Under Targets and Tagmentation (CUT&Tag) showed the co-localization of IRF2BP2 with several master transcription factors on chromatin in J.gamma1 cells.

2024-10-26 | GSE267451 | GEO

IRF2BP2 affects T-ALL cell proliferation by cooperating with master transcription factors

Project description:IRF2BP2 affects T-ALL cell proliferation by cooperating with master transcription factors

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IRF2BP2 affects T-ALL cell proliferation by cooperating with master transcription factors

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-10-26 | GSE267455 | GEO

IRF2BP2 affects T-ALL cell proliferation by cooperating with master transcription factors [Cut&Tag]

Project description:IRF2BP2 affects T-ALL cell proliferation by cooperating with master transcription factors [Cut&Tag]

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IRF2BP2 affects T-ALL cell proliferation by cooperating with master transcription factors [RNA-Seq]

Project description:IRF2BP2 affects T-ALL cell proliferation by cooperating with master transcription factors [RNA-Seq]

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Enhancer looping protein LDB1 affects T-ALL cell proliferation by cooperating with master transcription factors [RNA-Seq]

Project description:LIM domain-binding protein 1 (LDB1) is a highly conserved and widely expressed chromatin looping protein that connects enhancer-promoter genes through LIM and LIM homologous domains in various cell types. LDB1 has been confirmed to play a crucial role in various physiological and pathological processes. In our study, we aim to investigate the function and mechanisms of LDB1 in the context of T-cell acute lymphoblastic leukemia (T-ALL). RNA-seq was conducted and the differently expressed genes were revealed in the LDB1-knockdown 6T-CEM and J.gamma1 cells in comparison to control group. Cleavage Under Targets and Tagmentation (CUT&Tag) showed the co-localization of LDB1 with several master transcription factors on chromatin in 6T-CEM cells.

2024-10-15 | GSE253038 | GEO

Enhancer looping protein LDB1 affects T-ALL cell proliferation by cooperating with master transcription factors [CUT&Tag]

2024-10-15 | GSE252992 | GEO

IRF2BP2 promotes neuroblastoma progression

Project description:We report a previously unrecognized role of IRF2BP2 in neuroblastoma. To explore IRF2BP2-dependent gene regulation, RNA-seq analysis was conducted and the differently expressed genes were revealed in the IRF2BP2-knockdown SK-N-BE(2) cells in comparison to control group. We find that IRF2BP2 contributes to maintenance ADRN signature of neuroblastoma cell.

2024-06-24 | GSE236390 | GEO

Enhancer looping protein LDB1 affects T-ALL cell proliferation by cooperating with master transcription factors

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-10-15 | GSE253040 | GEO

Transcriptional regulation of adipocyte lipolysis by IRF2BP2 [ChIP-seq]

Project description:Adipocyte lipolysis controls systemic energy levels and metabolic homeostasis. Lipolysis is regulated by post-translational modifications of key lipolytic enzymes. However, less is known about the transcriptional mechanisms that regulate lipolysis. Here, we identify the transcriptional factor interferon regulatory factor-2 binding protein 2 (IRF2BP2) as a repressor of adipocyte lipolysis. Deletion of IRF2BP2 in primary human adipocytes increases lipolysis without affecting glucose uptake, whereas IRF2BP2 overexpression decreases lipolysis. RNA-seq and ChIP-seq analyses reveal that IRF2BP2 directly represses several lipolysis-related genes, including LIPE (HSL, hormone sensitive lipase), which encodes the rate-limiting enzyme in lipolysis. Adipocyte-selective deletion of Irf2bp2 in mice increases Lipe expression and free fatty acid levels, resulting in elevated adipose tissue inflammation and glucose intolerance. Altogether, these findings demonstrate that IRF2BP2 restrains adipocyte lipolysis and opens new avenues to target lipolysis for the treatment of metabolic disease.

2024-11-14 | GSE281495 | GEO

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