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IRF2BP2 affects T-ALL cell proliferation by cooperating with master transcription factors [Cut&Tag]

ABSTRACT: IRF2BP2 affects T-ALL cell proliferation by cooperating with master transcription factors [Cut&Tag]

PROVIDER: PRJNA1111543 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29024343_1.fastq.gz	Fastqsanger.gz
	SRR29024343_2.fastq.gz	Fastqsanger.gz
	SRR29024344_1.fastq.gz	Fastqsanger.gz
	SRR29024344_2.fastq.gz	Fastqsanger.gz
	SRR29024345_1.fastq.gz	Fastqsanger.gz

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IRF2BP2 affects T-ALL cell proliferation by cooperating with master transcription factors [Cut&Tag]

Project description:Knocking down IRF2BP2 led to decreased T-cell acute lymphoblastic leukemia (T-ALL) cell survival and growth both in vitro and in vivo. To explore IRF2BP2-dependent gene regulation, RNA-seq analysis was conducted and the differently expressed genes were revealed in the IRF2BP2-knockdown J.gamma1 cells in comparison to control group. Cleavage Under Targets and Tagmentation (CUT&Tag) showed the co-localization of IRF2BP2 with several master transcription factors on chromatin in J.gamma1 cells.

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IRF2BP2 affects T-ALL cell proliferation by cooperating with master transcription factors

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IRF2BP2 affects T-ALL cell proliferation by cooperating with master transcription factors [RNA-Seq]

Project description:IRF2BP2 affects T-ALL cell proliferation by cooperating with master transcription factors [RNA-Seq]

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IRF2BP2 affects T-ALL cell proliferation by cooperating with master transcription factors [RNA-Seq]

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Occupancy profiling of IRF2BP2, MYCN, AP-1 and SOX11 by CUT&Tag from Neuroblastoma cells

Project description:MYCN and SOX11 are master transcription factors (TFs) in neuroblastoma by directly occupying each other's and their own super-enhancers (SEs). Additionally, Master TFs cooperatively co-occupy the same SE components, which promotes the expression of IRF2BP2 involved in cell survival. We also observed the significant enrichment of the AP-1 family at the binding sites of IRF2BP2. In the present study, CUT&Tag (Cleavage Under Targets and Tagmentation) analysis was performed to explore the target of IRF2BP2, MYCN, AP-1 and SOX11 in NB cells.

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Enhancer looping protein LDB1 affects T-ALL cell proliferation by cooperating with master transcription factors [CUT&Tag]

Project description:Enhancer looping protein LDB1 affects T-ALL cell proliferation by cooperating with master transcription factors [CUT&Tag]

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Project description:Enhancer looping protein LDB1 affects T-ALL cell proliferation by cooperating with master transcription factors

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Enhancer looping protein LDB1 affects T-ALL cell proliferation by cooperating with master transcription factors [CUT&Tag]

Project description:LIM domain-binding protein 1 (LDB1) is a highly conserved and widely expressed chromatin looping protein that connects enhancer-promoter genes through LIM and LIM homologous domains in various cell types. LDB1 has been confirmed to play a crucial role in various physiological and pathological processes. In our study, we aim to investigate the function and mechanisms of LDB1 in the context of T-cell acute lymphoblastic leukemia (T-ALL). RNA-seq was conducted and the differently expressed genes were revealed in the LDB1-knockdown 6T-CEM and J.gamma1 cells in comparison to control group. Cleavage Under Targets and Tagmentation (CUT&Tag) showed the co-localization of LDB1 with several master transcription factors on chromatin in 6T-CEM cells.

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IRF2BP2 affects T-ALL cell proliferation by cooperating with master transcription factors

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-10-26 | GSE267455 | GEO