Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Tra2b's Ultraconserved Poison Exon relays TCR stimulation to shape T cell fate [ASO_RNASeq]

ABSTRACT: Analysis of transcript changes with enough depth for evaluation of splicing changes between CD8+ T cells from human donor PBMCs receiving no stimulation,CD3/CD28 stimulation plus scrambled ASO, or CD3/CD28 plus Tra2b-PE ASO

ORGANISM(S): Homo sapiens

PROVIDER: GSE267586 | GEO | 2024/06/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Tra2b's Ultraconserved Poison Exon relays TCR stimulation to shape T cell fate [PEKOSeq]

Project description:Analysis of transcript changes with enough depth for evaluation of splicing changes between scrambled control CD8+ T or Tra2b-PE KO CD8+ T cells from mice

2024-06-01 | GSE267601 | GEO

Tra2b's Ultraconserved Poison Exon relays TCR stimulation to shape T cell fate [CLIP-seq]

Project description:Analysis of Tra2b binding sites in Naïve and Effector CD8+ T cells from spleens and lymph nodes of OT-I mice unstimulated or stimulated with SIINFEKL peptide + anti-OX40/41BB for 4 days

2024-06-01 | GSE267587 | GEO

Tra2b's Ultraconserved Poison Exon relays TCR stimulation to shape T cell fate [mTorSeq]

Project description:Analysis of transcript changes with enough depth for evaluation of splicing changes between CD8+ T cells from mice receiving no stimulation, N4 stimulation, or N4 stimulation after treatment with Torin inhibitor

2024-06-01 | GSE267608 | GEO

Tra2b's Ultraconserved Poison Exon relays TCR stimulation to shape T cell fate

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-06-01 | GSE267609 | GEO

Tra2b's Ultraconserved Poison Exon relays TCR stimulation to shape T cell fate [N4T4Seq]

Project description:Analysis of transcript changes with enough depth for evaluation of splicing changes between CD8+ T cells from mice receiving high affinity SIINFEKL (N4) and moderate affinity SIITFEKL (T4) peptide + anti-OX40/anti-41BB costimulation

2024-06-01 | GSE267588 | GEO

Tra2b's Ultraconserved Poison Exon relays TCR stimulation to shape T cell fate [Tra2bKO]

Project description:Analysis of transcript changes with enough depth for evaluation of splicing changes between naïve, scrambled control CD8+ T or Tra2bKO CD8+ T cells from mice

2024-06-01 | GSE267603 | GEO

RNA-seq profiling of in vitro FRC-conditioned, IL6-conditioned or control (anti-CD3/CD28)-stimulated CD8+ T cells

Project description:To broadly assess which pathways FRCs regulate in CD8+ T cells, we sorted CD8+ T cells for RNA-seq following activation in whole splenocyte mixtures via soluble anti-CD3/CD28 for 48 hours (Stim), activated with anti-CD3/CD28 in the presence of Nos2–/– FRCs (FRC) or activated with anti-CD3/CD28 plus 100 ng/ml recombinant IL-6 (IL-6). Here we demonstrate that FRC-derived signals, including IL-6, act in concert with TCR signaling and co-stimulation to promote the expression of MYC and HIF-1-dependent glycolytic genes and vital pro-survival genes (encoding BCL-2 family members, inhibitors of apoptosis [IAPs] members and Cflar) in activated CD8+ T cells.

2019-10-14 | GSE136898 | GEO

Role of Dec1 transcription factor in naive CD4+ T cell activation transcriptome

Project description:We used microarrays to detail the global gene transcription effect of Dec1 underlying T cells activation during the first 24 hours after stimulation. CD4+CD62LhiCD25- T cells were sorted and cultured with different stimulatory conditions (anti-CD3 and anti-CD3 plus anti-CD28) for 24 hours. 4 replicates for each condition were analyzed.

2013-07-03 | E-GEOD-39595 | biostudies-arrayexpress

Human naive CD4+ T cell activation transcriptome

Project description:We used microarrays to detail the global gene transcription underlying T cells activation during the first 24 hours after stimulation. CD4+CD45RA+ T cells were sorted and cultured with different stimulatory conditions (Non-stimulated, anti-CD3 and anti-CD3 plus anti-CD28) for different times (0 hours, 4 hours and 24 hours). 3 replicates for each condition were analyzed.

2013-07-03 | E-GEOD-39594 | biostudies-arrayexpress

ATAC-seq profiling of in vitro FRC-conditioned, IL6-conditioned or control (anti-CD3/CD28)-stimulated CD8+ T cells

Project description:To broadly assess which pathways FRCs regulate in CD8+ T cells, we sorted CD8+ T cells for ATAC-seq following activation in whole splenocyte mixtures via soluble anti-CD3/CD28 (0.25μg/ml) for 48 hours (Stim), activated with anti-CD3/CD28 in the presence of Nos2–/– FRCs (FRC) or activated with anti-CD3/CD28 plus 100 ng/ml recombinant IL-6 (IL-6). Here we demonstrate that FRC-derived signals, including IL-6, act in concert with TCR signaling and co-stimulation to remodel chromatin and render essential transcription factor binding motifs accessible in activated CD8+ T cells. Signals from FRCs led to increased binding regions for MYC, HIF-1α and HIF-1β, which are known to promote metabolic pathways following T cell activation. Additionally, FRC-derived signals promoted activity of transcription factors that regulate survival and memory programs in T lymphocytes such as BATF and BACH2.

2019-10-14 | GSE136903 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data