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Transcriptome landscape of the adrenal gland and superior cervical ganglion from hypertension-induced left ventricular hypertrophy rat model

ABSTRACT: Hypertension-induced left ventricular hypertrophy (LVH) is a cardiac structural remodeling and dysfunction resulting from chronic hypertension and is an independent risk factor for cardiovascular morbidity and mortality. Studies have implicated the involvement of the adrenal gland (AG) and superior cervical ganglion (SCG) in hypertension regulation. However, the molecular mechanisms of AG and SCG during hypertension-induced LVH remain unclear. In this study, we investigated the transcriptome characteristics of the left ventricle, AG, and SCG in 24-week-old spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats using transcriptome sequencing (RNA-seq) technology. We identified 671 differentially expressed genes (DEGs) in the left ventricle, 1596 DEGs in the AG, and 343 DEGs in the SCG between SHR and WKY rats. Functional analysis revealed that these DEGs were involved in pathways related to immune inflammation, metabolic responses, and synaptic transmission. Further analysis demonstrated the presence of crosstalk among DEGs across these three organs, including 63 overlapping DEGs among these three organs, of which 59 DEGs exhibited consistent changes. In summary, we elucidates the transcriptome features of AG and SCG during hypertension-induced LVH in SHR, highlighting the complex molecular interactions across multiple organs.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE267794 | GEO | 2024/06/17

REPOSITORIES: GEO

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