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Transcription profiling of feft ventricle in three genetic rat models of hypertension

ABSTRACT: Left ventricle gene expression was analyzed in three models of hypertension in order to clarify the molecular mechanisms associated with left ventricular hypertrophy. Transgenic heterozygous TGR(mRen2)27 rats, overexpressing the mouse renin gene, and their littermate negative controls, spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY), and Lyon hypertensive rats (LH) and their normotensive controls (LL) were included in the study.

ORGANISM(S): Rattus norvegicus

DISEASE(S): hypertension

SUBMITTER: Mazen Kurdi

PROVIDER: E-MEXP-357 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcriptional alterations in the left ventricle of three hypertensive rat models.

Cerutti Catherine C Kurdi Mazen M Bricca Giampiero G Hodroj Wassim W Paultre Christian C Randon Jacques J Gustin Marie-Paule MP

Physiological genomics 20060801 3

Left ventricular hypertrophy (LVH) is commonly associated with hypertension and represents an independent cardiovascular risk factor. The aim of this study was to test the hypothesis that the cardiac overload related to hypertension is associated to a specific gene expression pattern independently of genetic background. Gene expression levels were obtained with microarrays for 15,866 transcripts from RNA of left ventricles from 12-wk-old rats of three hypertensive models [spontaneously hypertens ...[more]

PMID: 16882881

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