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Hippocampal single-cell atlas screening unveils disrupted neuroglial system in postoperative cognitive impairment

ABSTRACT: This study investigates the roles of neurons, microglia, astrocytes, and oligodendrocytes in the pathogenesis of postoperative cognitive impairment, focusing on a dysregulated glia-neuron cycle. We utilized 18-month male C57BL/6 mice to model this condition, conducting single-cell RNA sequencing in the hippocampus to explore the neuroglial interactions and their implications in neuroinflammation, synaptic dysfunction, and myelin loss. This dataset includes transcriptomic profiles aimed at decoding the cellular communication in aged hippocampal cells and assessing the impact of therapeutic interventions on postoperative cognitive decline.

ORGANISM(S): Mus musculus

PROVIDER: GSE267933 | GEO | 2024/11/14

REPOSITORIES: GEO

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Hippocampal single-cell atlas screening unveils disrupted neuroglial system in postoperative cognitive impairment

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