Transcriptomics

Dataset Information

0

Interleukin-2 receptor signaling acts as a checkpoint that shapes the distribution of regulatory T cell subsets (scRNA-Seq)


ABSTRACT: Regulatory T cells (Tregs) require IL-2 for survival in the periphery, yet how IL-2 shapes Treg heterogeneity remains poorly defined. Here we found that inhibition of IL-2R signaling in post-thymic Tregs leads to a preferential early loss of central Tregs (cTregs). Gene expression of cTregs was more dependent on IL-2R signaling than effector Tregs (eTregs). Unexpectedly, ablation of IL-2R signaling in cTregs resulted in increased proliferation, expression of eTreg genes, and enhanced capacity to develop into eTregs. These findings indicate that physiological amounts of IL-2 act as a checkpoint to maintain cTreg homeostasis and tolerance while restraining their development into eTregs. Nevertheless, direct evaluation of eTregs revealed that loss of IL-2R signaling alters the distribution of eTreg subsets, with increased IFNgR1+ eTregs and CXCR5+ PD-1+ T follicular regulatory (TFR) cells but decreased intestinal RORgt+ TR17 cells. Thus, IL-2R signaling also shapes the development of specialized eTregs subsets.

ORGANISM(S): Mus musculus

PROVIDER: GSE268022 | GEO | 2024/10/18

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2024-10-18 | GSE268021 | GEO
2021-05-11 | GSE164937 | GEO
2018-05-18 | GSE90600 | GEO
2018-05-18 | PXD007744 | Pride
2018-05-18 | PXD007745 | Pride
2018-05-18 | PXD005477 | Pride
2019-02-01 | GSE121883 | GEO
2021-04-01 | GSE166713 | GEO
2012-08-06 | E-GEOD-36527 | biostudies-arrayexpress
2023-07-21 | GSE225737 | GEO