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Spatial Transcriptomics and Network-Based Bioinformatics Differentiate Intestinal Phenotypes of Cardiac and Classical Necrotizing Enterocolitis

ABSTRACT: Classical necrotizing enterocolitis (classical NEC) is a devastating gastrointestinal disease of the neonatal period, and cardiac NEC is a subset of the disease occurring in infants with comorbid congenital heart disease. Despite nearly identical symptomatology, the two NEC subtypes may represent etiologically distinct diseases. We used spatial transcriptomics and network analyses to compare tissue regions of interest derived from surgically resected ileum of patients with cardiac and classical NEC, finding evidence classical and cardiac NEC may arise from differing etiologies.

ORGANISM(S): Homo sapiens

PROVIDER: GSE268423 | GEO | 2024/11/28

REPOSITORIES: GEO

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