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Multiomic-based Immune Response Profiling in Migraine, Vestibular Migraine and Meniere's Disease [scATAC-Seq]

ABSTRACT: We analysed the immune profile of individuals with MI, VM, and MD using scRNAseq and scATACseq in PBMCs and to determine active biochemical pathways to identify new potential druggable molecular targets

ORGANISM(S): Homo sapiens

PROVIDER: GSE269114 | GEO | 2024/09/15

REPOSITORIES: GEO

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Multiomic-based Immune Response Profiling in Migraine, Vestibular Migraine and Meniere's Disease

Project description:We analysed the immune profile of individuals with MI, VM, and MD using scRNAseq and scATACseq in PBMCs and to determine active biochemical pathways to identify new potential druggable molecular targets

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A high-resolution single-cell multiomic atlas of the human fetal lung - ATAC-seq

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Multiomic-based Immune Response Profiling in Migraine, Vestibular Migraine and Meniere's Disease [scATAC-Seq]

Project description:Multiomic-based Immune Response Profiling in Migraine, Vestibular Migraine and Meniere's Disease [scATAC-Seq]

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Multiomic-based Immune Response Profiling in Migraine, Vestibular Migraine and Meniere's Disease

Project description:Multiomic-based Immune Response Profiling in Migraine, Vestibular Migraine and Meniere's Disease

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Integrated multiomics (scATACseq and scRNAseq) of 2D10 cells treated with small molecules for 24hrs

Project description:Integrated multiomics (scATACseq and scRNAseq) of 2D10 cells treated with small molecules for 24hrs.

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Single cell analysis of transcriptome and open chromatin reveals the dynamics of hair follicle stem cell aging [scATAC-Seq]

Project description:As the biggest organ of human body, skin and its appendages offer excellent experimental systems for aging studies. Skin wrinkling, hair greying and hair loss are among the most striking and observable traits of aging. However, the chronic changes and cell-to-cell variation accumulated during aging in different hair follicle lineages remain unexplored. Here we present a detailed analysis of scRNAseq and scATACseq data from young and aging animals. We found distinct cellular state changes of individual hair follicle populations.

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Auditory Manifestations of Vestibular Migraine.

Project description:ObjectivesTo investigate the auditory features of patients with vestibular migraine (VM) and to analyze the possible relevant factors of hearing loss.MethodsA total of 166 patients with VM were enrolled. Demographic variables, age of onset, disease course, distribution of vestibular attacks, characteristics of hearing loss, and the coexistence of related disorders, such as visual aura, familial history, motion sickness, nausea, headache, photophobia, otalgia, tinnitus, aural fullness, and phonophobia, were analyzed and compared.ResultsPatients with VM can manifest otalgia (8.4%), tinnitus (51.8%), aural fullness (41%), and phonophobia (31.9%). Of 166 patients, the prevalence of VMw was 21.1% (n = 35). Patients with VMw mainly manifested mild and easily reversible low-frequency hearing loss. The proportions of tinnitus and aural fullness were significantly larger in patients with VMw than that in patients with VMo (P < 0.05). The duration of vestibular symptoms was significantly shorter in patients with VMw (P < 0.05). However, the age of onset, disease course, gender, frequency of vestibular attacks, the coexistence of visual aura, familial history, motion sickness, nausea, headache, photophobia, otalgia, and phonophobia had no significant difference between the two groups.ConclusionAuditory symptoms were common in patients with VM. The hearing loss of VM was characterized by a mild and easily reversible low-frequency hearing loss, accompanied by higher proportions of tinnitus and aural fullness, and a shorter duration of vestibular symptoms compared with patients with VMo.

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Association Between Vestibular Migraine and Migraine Headache: Yet to Explore.

Project description:ObjectivesTo evaluate if patients with a diagnosis of vestibular migraine (VM) by the International Classification of Headache Disorders (ICHD) criteria have meaningful differences in symptomatology and disease characteristics when compared to patients with concurrent vestibular symptoms and migraine that do not meet ICHD criteria.MethodsPatients who presented for the evaluation of vertigo were provided a detailed questionnaire about dizziness and migraine symptoms. Patients were assigned to either VM cohort (met ICHD criteria for VM) or migraine headache (MH) cohort (met ICHD criteria for migraine with or without aura but not VM). Disease characteristics, symptomatology, quality of life, and perceived stress score were compared between the cohorts.ResultsThe VM cohort demonstrated a shorter duration of vertigo episodes, 11 ± 22 hours versus 84 ± 146 hours in the MH cohort. In the VM cohort, 81% reported experiencing migraine headaches during episodes of vertigo, versus 61% in the MH cohort. All patients in the VM cohort reported a previous diagnosis of migraine headache, whereas 9% of the MH cohort had not been previously diagnosed by another physician. There was no difference in quality of life or perceived stress scores between the cohorts.ConclusionsA large proportion of vertigo patients with migrainous features do not meet the ICHD criteria for VM. The differences between cohorts represent selection bias rather than meaningful features unique to the cohorts. As such, VM and MH with vestibular symptoms may exist on a spectrum of the same disease process and may warrant the same treatment protocols.

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Diagnostic Value of the Vestibular Autorotation Test in Meniere's Disease, Vestibular Migraine and Meniere's Disease with Migraine.

Project description:(1) Background: Vestibular migraine (VM) and Menière's disease (MD) share multiple features in terms of clinical presentations and auditory-vestibular functions, and, therefore, more accurate diagnostic tools to distinguish between the two disorders are needed. (2) Methods: The study was of retrospective design and examined the data of 69 MD patients, 79 VM patients and 72 MD with migraine patients. Five vestibular autorotation test (VAT) parameters, i.e., horizontal gain/phase, vertical gain/phase and asymmetry were subjected to logistic regression. The receiver operating characteristic (ROC) curves were generated to determine the accuracy of the different parameters in the differential diagnosis of MD and VM. (3) Results: Our results showed that the horizontal gain of VAT significantly outperformed other parameters in distinguishing MD and VM. In addition, the sensitivity, specificity and accuracy of the horizontal gain were 95.7%, 50.6% and 71.6%, respectively, for the differentiation between VM and MD. In most MD patients, the horizontal gain decreased in the range of 3-4 Hz, while in most VM patients, horizontal gain increased in the range between 2-3 Hz. More MD with migraine patients had an increased horizontal gain when the frequency was less than 5.0 Hz and had a decreased horizontal gain when the frequency was greater than 5.0 Hz. (4) Conclusion: Our study suggested the VAT, especially the horizontal gain, as an indicator, may serve as a sensitive and objective indicator that helps distinguish between MD and VM. Moreover, VAT, due to its non-invasive and all-frequency nature, might be an important part of a test battery.

| S-EPMC9688433 | biostudies-literature

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