Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gestational exposure to environmental chemicals and epigenetic alterations in the placenta and cord blood mononuclear cells

ABSTRACT: This study includes 75 pregnant individuals, where associations between 37 endocrine disrupting chemical biomarkers and methylation intensities were assessed using multiple linear regression. Methylation intensities were quantified from cord blood mononuclear cells and cord blood. The DNA methylation profiles were generated using the Illumina Infinium HumanMethylation450 Beadchip that measured about 450,000 CpGs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE269983 | GEO | 2024/06/19

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Exposure to Gestational Diabetes Mellitus In Utero Alters DNA Methylation in Placenta and Fetal Cord Blood [Placenta]

Project description:Genome wide DNA Methylation in fetal cord blood and placenta from mother with GDM compared to mother with normal glucose tolerance

2021-01-31 | GSE153220 | GEO

Epigenome analysis of DNA from umbilical cord blood (UCWBC) in CCCEH birth cohort

Project description:Genome wide DNA methylation profiling of 152 umbilical cord blood samples from CCCEH birth cohort. The Illumina Infinium 450k Human DNA methylation Beadchip was used to obtain DNA methylation profiles across approximately 450,000 CpGs in cord blood samples

2017-07-17 | GSE69176 | GEO

Epigenome analysis of CHAMACOS cord blood

Project description:Genome wide DNA methylation profiling of CHAMACOS cord blood. The Illumina Infinium 450k Human DNA methylation Beadchip was used to obtain DNA methylation profiles across approximately 450,000 CpGs. Methylation was assessed in 380 cord blood samples of members of the CHAMACOS cohort.

2017-05-31 | GSE97628 | GEO

Exposure to Gestational Diabetes Mellitus In Utero Alters DNA Methylation in Placenta and Fetal Cord Blood [Cord]

Project description:Genome wide DNA Methylation in fetal cord blood and placenta from mother with GDM compared to mother with normal glucose tolerance

2021-01-31 | GSE153219 | GEO

Gestational exposure to environmental chemicals and epigenetic alterations in the placenta and cord blood mononuclear cells

Project description:Gestational exposure to environmental chemicals and epigenetic alterations in the placenta and cord blood mononuclear cells

| PRJNA1124555 | ENA

Epigenome analysis of Peripheral Blood samples from 53 pediatric ASD patients and 10 pediatric controls

Project description:Genome wide DNA methylation profiling of blood samples from patients with ASD and controls. The IlluminaInfinium HumanMethylation450 BeadChip was used to obtain DNA methylation profiles across approximately 450,000 CpGs. Samples included 53 individuals with idiopathic ASD (aged 2 to 14) and 10 age-matched controls.

2016-07-12 | GSE83424 | GEO

Genome wide DNA methylation profiling of post-exercise milk product intake during interval walking training.

Project description:Genome wide DNA methylation profiling of post-exercise milk product intake during interval walking training. The Illumina Infinium HumanMethylation450 BeadChip was used to obtain DNA methylation profiles across approximately 450,000 CpGs in peripheral blood samples. Samples include 24 subjects (12, placebo intake; 12, milk product intake).

2017-06-09 | GSE76503 | GEO

Methylation for adult blood and cord blood samples

Project description:Good quality standard adult blood samples and cord blood samples hybridized to the Illumina Infinium HumanMethylation450 BeadChip and used as methylation controls.

2020-11-27 | GSE149572 | GEO

Interplay between Histone and DNA Methylation Seen through Comparative Methylomes in Rare Mendelian Disorders

Project description:Genome wide DNA methylation profiling of blood samples from patients with genetic diseases of the epigenetic machineries. The Illumina Infinium HumanMethylation450 and the Infinium MethylationEPIC BeadChips were used to obtain DNA methylation profiles across approximately 450,000 and 850,000 CpGs in whole blood from patients with ICF and overgrowth syndrome. Samples included 1 ICF1, 2 ICFX, 2 TBRS and 2 Luscan-Lumish patients.

2021-05-25 | GSE167230 | GEO

Reduced representation bisulfite sequencing (RRBS) methylation profiles of placenta and umbilical cord blood with or without gestational diabetes mellitus (GDM)

Project description:Objective: To explore the characteristics and underlying molecular mechanisms of genome-scale expression profiles of women with- or without- gestational diabetes mellitus and their offspring. Materials and Methods: We recruited a group of 21 pregnant women with gestational diabetes mellitus (GDM) and 20 healthy pregnant women as controls. For each pregnant women, RRBS were performed using the placenta and paired neonatal umbilical cord blood specimens. Differentially methylated regions (DMRs) were identified. Then, functional enrichment analysis was performed to differential methylated genes (DMGs) separately or interactively in placenta and umbilical cord blood. Results: Through the comparison of GDM and healthy samples, 2779 and 141 DMRs were identified from placenta and umbilical cord blood, respectively. Functional enrichment analysis showed that the placenta methylation and expression profiles of GDM women mirrored the molecular characteristics of “type II diabetes” and “insulin resistance”. Methylation-altered genes in umbilical cord blood were associated with pathways “type II diabetes” and “cholesterol metabolism”. DMGs illustrated significant overlaps among placenta and umbilical cord blood samples, and the overlapping DMGs were associated with cholesterol metabolism. Conclusions: Our research demonstrated the epigenomic alternations of GDM mothers and offspring. Our findings emphasized the importance of epigenetic modifications in the communication between pregnant women with GDM and offspring, and provided reference for the prevention, control, treatment, and intervention of perinatal deleterious events of GDM and neonatal complications.

2022-05-31 | GSE203169 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data