Transcriptomics

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Bulk RNAseq of adult Drosophila melanogaster whole brains with neuronal specific knock down of brummer.


ABSTRACT: Lipids are essential for neuron development and physiology. Lipid droplets (LD) play a central role in coordinating cellular lipid distribution and metabolism in non-neuronal cells; however, there is no general consensus on a role for neuronal LD under normal physiological conditions. We have previously shown that neuronal LD exists in wildtype flies under normal physiological condition, and that the loss of a triglyceride lipase, brummer, increases neutral lipids in the brain (Wat et al., 2020). To investigate the importance of brummer in regulating neuronal metabolism and function in a sex-specific manner, we performed transcriptomic profiling in adult male and female whole brain with RNAi-mediated neuron-specific knock down of brummer.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE270119 | GEO | 2024/09/19

REPOSITORIES: GEO

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