Transcriptomics

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Tau accumulation induces microglial state alterations in Alzheimer’s disease model mice (snRNA-seq, part 1)


ABSTRACT: Unique microglial states have been identified in Alzheimer’s disease (AD) model mice and postmortem AD brains. Although it has been well documented that amyloid-β accumulation induces the alteration of microglial states, the relationship between tau pathology and microglial states remains incompletely understood because of a lack of suitable AD models. In the present study, we generated a novel AD model mouse by the intracerebral administration of tau purified from human brains with primary age-related tauopathy into AppNL-G-F/MAPT double knock-in (dKI) mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE270385 | GEO | 2024/12/16

REPOSITORIES: GEO

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