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Deficiency of gut-enriched Lipase H promotes gut aging and reduces lifespan in Drosophila

ABSTRACT: Liph, a gut-enriched Lipase H encoding gene, shows decreased expression during gut aging in both fruit fly and mouse. However, whether such evolutionary conserved Liph plays a protective role in gut aging remains unknown. In this study, RNA-seq was performed on gut tissue from fly model to identify changes in gene expression produced in whole guts after knocking down CG6295, the Drosophila ortholog of the mammalian Liph. In addition, we performed RNA-seq analysis on rat intestinal epithelial IEC-6 cells with Liph knockdown to investigate the role of Liph in mammalian intestinal aging.

ORGANISM(S): Rattus norvegicus Drosophila melanogaster

PROVIDER: GSE270707 | GEO | 2024/06/28

REPOSITORIES: GEO

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