Transcriptomics

Dataset Information

0

Serum exosomes lncRNAs: TCONS_I2_00013502 and ENST00000363624 are new diagnostic markers for rheumatoid arthritis


ABSTRACT: The lack of diagnostic markers limits the window of effectiveness for rheumatoid arthritis (RA) therapies. Here, we isolated exosomes of serum samples from four distinct groups RA patients, according to disease activity and with/without medication. Then, total RNA of exosomes was extracted for whole-transcriptome sequencing. Focusing on lncRNA sequencing, gene ontology (GO) and kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analyses were performed. We found that the number of upregulated lncRNAs were significantly higher than that of downregulated lncRNAs in each four RA groups. And most importantly, we identified two specific lncRNAs from differentially expressed lncRNAs, TCONS_I2_00013502 (up-regulated) and ENST00000363624 (down-regulated) in RA. Receiver Operating Characteristic (ROC) curve analysis showed that the two lncRNAs were promising biomarkers for RA diagnosis. These findings highlight lncRNAs of the serum exosome are important biomarkers and provide application potential for diagnosis of RA.

ORGANISM(S): Homo sapiens

PROVIDER: GSE271161 | GEO | 2024/07/04

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2023-03-11 | PXD037341 | Pride
2019-12-31 | GSE94519 | GEO
2022-11-07 | GSE217299 | GEO
2021-02-25 | PXD004546 | Pride
2021-06-05 | GSE176134 | GEO
2022-03-30 | GSE199509 | GEO
2021-06-08 | GSE173719 | GEO
2024-10-25 | GSE272078 | GEO
2024-10-25 | GSE272079 | GEO
2022-04-19 | PXD032912 | Pride