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Systematic functional characterization of the non-coding regulatory SNPs associated with central obesity

ABSTRACT: Genome-wide association studies (GWASs) have identified more than 300 susceptibility loci associated with central obesity. However, the functional understanding of these loci is limited by the fact that most loci are in the non-coding region. To address this issue, in this study we firstly selected 2,034 prioritized SNPs based on fine-mapping and epigenomic annotation analysis. Self-transcribing active regulatory region sequencing (STARR-seq) experiment was then performed to systematically assess the enhancer activity of these prioritized SNPs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE271195 | GEO | 2025/01/02

REPOSITORIES: GEO

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