Hemoglobin-induced Transcriptomic Changes in Human Cerebral Arteries
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ABSTRACT: Hemoglobin (Hb) in the subarachnoid space significantly impacts cerebral vessels, leading to various pathological outcomes. The toxicity of cell-free Hb released from erythrocytes and its metabolites is suggested to cause vasoconstriction and neuronal damage, correlating with delayed ischemic neurological deficits (DIND). Here, we aim to describe the changes in the genetic profile of human cerebral arteries exposed to free Hb for 48 hours. We performed an ex vivo treatment followed by mRNA sequencing of the vessels
ORGANISM(S): Homo sapiens
PROVIDER: GSE271989 | GEO | 2024/07/15
REPOSITORIES: GEO
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