Transcriptomics

Dataset Information

0

Translation inhibition with CHX in mouse embryonic stem cells in bulk


ABSTRACT: Gene-expression noise can influence cell-fate choices across pathology and physiology. However, a crucial question persists: do regulatory proteins or pathways exist that control noise independently of mean expression levels? Our integrative approach, combining single-cell RNA sequencing with proteomics and regulator enrichment analysis, reveals 32 putative noise regulators. The approach utilizes global translation inhibition (i.e., potential protein regulators), and single-cell RNA sequencing (scRNA-seq) to quantify the changes in noise of all transcripts (i.e., potential mRNA targets). This dataset corresponds to a control bulk RNAseq experiment experiment upon translation inhibition with cycloheximide to validate the changes in mean observed with single-cell.

ORGANISM(S): Mus musculus

PROVIDER: GSE272056 | GEO | 2024/08/05

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2024-08-05 | GSE271660 | GEO
2005-11-03 | GSE3543 | GEO
2005-11-03 | E-GEOD-3543 | biostudies-arrayexpress
2024-08-05 | GSE270846 | GEO
2024-08-05 | GSE271082 | GEO
2011-01-01 | GSE20175 | GEO
2018-05-01 | PXD006886 | Pride
2011-01-01 | E-GEOD-20175 | biostudies-arrayexpress
| PRJNA552720 | ENA
2014-07-12 | GSE55346 | GEO