Transcriptomics

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Targeted single cell expression profiling identifies integrators of sleep and metabolic state


ABSTRACT: The fruit fly, Drosophila melanogaster, suppresses sleep in response to acute food deprivation, presumably to forage for food. This process is dependent on a single pair of neurons, termed the Lateral Horn Leucokinin (LHLK) neurons, that secrete the neuropeptide Leucokinin. These neurons signal to insulin producing cells and suppress sleep under periods of starvation. Here, we use single-cell sequencing of LHLK neurons to examine the transcriptional responses to starvation.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE272264 | GEO | 2024/09/27

REPOSITORIES: GEO

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