Genomics

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Analysis of the impact of cellular miRNA signatures on the profiles of circulating miRNA biomarkers (fractionation data)


ABSTRACT: Circulating miRNAs are an emerging class of biomarkers correlating their specific expression patterns to disease states. A considerable proportion of hematopoietically-derived miRNAs are present in plasma with the ability to confound the signature of true circulating miRNA species. We use microarray analysis to catalogue a list of 313 haemotopoetic miRNAs and analyze expression profiles of cell-free miRNAs in individual plasma fractions after calibrating for cellular miRNA signals. Comprehensive global maps of bona fide circulating miRNA species are presented, and inter-individual variability and gender-specific expression is explored in populations of healthy individuals.

ORGANISM(S): synthetic construct Homo sapiens

PROVIDER: GSE27230 | GEO | 2011/06/17

SECONDARY ACCESSION(S): PRJNA141965

REPOSITORIES: GEO

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