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METTL5 deficiency induces lung cancer regression via mitochondrial translation reduction

ABSTRACT: Cellular protein synthesis occurs through two types of translation: cytoplasmic and mitochondrial. These two types of translation operate independently but in coordination to regulate cell survival and death. Methyltransferase-like 5 (METTL5) has been found to play a role in directing the m6A modification of rRNA, which in turn controls cytoplasmic translation and impacts the decisions related to cell fate. In this study, we employed Ribo-seq to explore the effects of METTL5 deficiency on both cytoplasmic and mitochondrial translation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE272389 | GEO | 2025/03/01

REPOSITORIES: GEO

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METTL5 deficiency induces lung cancer regression via mitochondrial translation reduction

Project description:METTL5 deficiency induces lung cancer regression via mitochondrial translation reduction

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