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Retinoic acid modulation of conserved longevity pathways in genetically-diverse Caenorhabditis nematodes.

ABSTRACT: We present a survey of longevity effects for compounds suggested by a previously published computational prediction set using the comprehensive, multi-species approach utilized by the Caenorhabditis Intervention Testing Program (CITP). The compound all-trans retinoic acid extended lifespan in the nematode Caenorhabditis elegans. Given the dependency of lifespan extension under atRA treatment, we used RNA-seq to assess transcriptional changes under atRA treatment in wildtype N2 animals. In order to further dissect transcriptional response in detail, we repeated our transcriptional analysis in hsf-1(sy441) and aak-2(ok524) mutants.

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE272535 | GEO | 2024/10/22

REPOSITORIES: GEO

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Retinoic acid modulation of conserved longevity pathways in genetically-diverse Caenorhabditis nematodes.

Project description:Retinoic acid modulation of conserved longevity pathways in genetically-diverse Caenorhabditis nematodes.

| PRJNA1137311 | ENA

nematodes

Project description:Caenorhabditis. briggsae and Caenorhabditis. nigoni Raw sequence reads

| PRJNA1125123 | ENA

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