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Synthesis of 2'-formamidonucleoside phosphoramidites for suppressing the seed-based off-target effects of siRNAs

ABSTRACT: To investigate effects of siRNA with 2'-formamidonucleoside phosphoramidites (2'-FA) modifications on genome-wide off-target, we analyzed gene expression profile of HeLa cells transfected by their siRNAs. Gene expression profiling

ORGANISM(S): Homo sapiens

PROVIDER: GSE274299 | GEO | 2024/09/30

REPOSITORIES: GEO

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Synthesis of 2'-formamidonucleoside phosphoramidites for suppressing the seed-based off-target effects of siRNAs [RNA-seq]

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