Transcriptomics

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Single cell transcriptomics of human epidermis shows decreased expression of several structural genes associated with skin barrier development in aged skin


ABSTRACT: Epidermal keratinocytes are continuously dividing cells which, upon differentiation establish the outer skin barrier, the stratum corneum. In older age the epidermis becomes thinner, papillary protrusions flatten and the capacity for skin barrier repair decreases. Here we performed single-cell RNA sequencing of epidermal keratinocytes obtained by suction blisters from the volar forearm of younger (20-30) and older (65-70) healthy female individuals.

ORGANISM(S): Homo sapiens

PROVIDER: GSE275846 | GEO | 2024/08/28

REPOSITORIES: GEO

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