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SIRT6 loss causes intervertebral disc degeneration in mice by dysregulating senescence and SASP status

ABSTRACT: Transcriptional analysis of 24-month-old primary nucleus pulposus (NP) and annulus fibrosus (AF) mouse disc tissues from Sirt6fl/fl and Sirt6cKO mice, which harbor a mutation which constiuitively deletes Sirtuin 6 in aggrecan expressing cells. SIRT6 loss causes intervertebral disc degeneration in mice by dysregulating senescence and SASP status

ORGANISM(S): Mus musculus

PROVIDER: GSE276439 | GEO | 2024/10/02

REPOSITORIES: GEO

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