Gene expression of wild-type or GC-A knockout mouse glomeruli treated with high salt diet and aldosterone infusion after uninephrectomy.
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ABSTRACT: Podocytes are integral to maintaining the glomerular filtration barrier and preventing proteinuria. Our previous research underscored the crucial role of podocyte guanylyl cyclase-A (GC-A) in the pathogenesis of severe albuminuria in both systemic and podocyte-specific GC-A knockout mice. In this study, we demonstrate that matrix metalloproteinase-10 (MMP-10) is highly expressed in the glomeruli of GC-A knockout mice and in the kidneys of patients with glomerulonephritis.
ORGANISM(S): Mus musculus
PROVIDER: GSE276626 | GEO | 2024/09/22
REPOSITORIES: GEO
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