Cell type-specific apoptosis resistance in juvenile myelomonocytic leukemia
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ABSTRACT: Juvenile myelomonocytic leukemia (JMML) is caused by constitutively activated RAS signaling. Activation of the RAS pathway in the JMML mouse model (MxCre;Ptpn11D61Y) affects apoptosis signaling by regulating BCL-2 family members through oncogenic and microenvironemtal signals, in a cell type-dependent manner. Apoptosis resistance mediated by overexpression of anti-apoptotic and downregulation of pro-apoptotic BCL-2 family members was observed in monocytes and granulocytes.
ORGANISM(S): Mus musculus
PROVIDER: GSE277667 | GEO | 2025/03/19
REPOSITORIES: GEO
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