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Itaconate modulates immune responses via inhibition of peroxiredoxin 5

ABSTRACT: Gene expression in WT BMDMs pretreated with itaconic acid, malonic acid or methylsuccinic acid.

ORGANISM(S): Mus musculus

PROVIDER: GSE277689 | GEO | 2025/02/14

REPOSITORIES: GEO

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Itaconate modulates immune responses via inhibition of peroxiredoxin 5

Project description:Wild type and Irg1 knockout mouse bone marrow derived macrophages (BMDMs) were processed with a redox proteomics workflow and analyzed by LC-MS/MS with TMT based quantification.

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Itaconate modulates immune responses via inhibition of peroxiredoxin 5

Project description:Itaconate modulates immune responses via inhibition of peroxiredoxin 5

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Project description:WT and ISG15 KO macrophages were stimulated with interferon-a and treated with itaconic acid and 4-octyl itaconate as they are known for anti-inflammatory effects. In this experiment, we further explored how itaconic acid and 4-octyl itaconate can play its role keeping ruxolitinib as a positive control in order to inhibit JAK/STAT pathway

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Expression data from hiPSC derived WT and ISG15 KO endothelial cells stimulated with interferon-a and treated with itaconic acid, dimethyl itaconate, 4-octyl itaconate and ruxolitinib

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Project description:Analysis of gene expression in human PBMCs infected with influenza A virus or Mock and treated with Itaconic acid, Dimethyl itaconate or 4-Octyl itaconate to investigate the effects itaconate have on transcriptional response in human PBMCs. We particularly looked at anti-inflammatory effects of itaconate in inflammation followed by Influenza A virus infection.

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Expression data from A549 cell line infected with influenza A virus (IAV) and treated with/without Itaconate

Project description:Analysis of gene expression in A549 cells infected with influenza A virus or Mock and treated with Itaconic acid (IA), or Dimethyl itaconate (DI) to investigate the effects itaconate have on transcriptional response in A549 cells. We particularly looked at anti-inflammatory effects of itaconate in inflammation followed by Influenza A virus infection.

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Expression data from differentiated THP-1 (dTHP-1) cell line infected with influenza A virus (IAV) and treated with/without Itaconate

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