Itaconate modulates immune responses via inhibition of peroxiredoxins

ABSTRACT: Itaconate is a natural mild electrophile, able to modify free thiols in proteins upon activation. We submit two datasets investigating peptides modified by itaconate. Experiment001 contains data obtained from endogenous itaconate producing WT or itaconate incompetent Irg1-/- Bone marrow-derived macrophages stimulated with LPS for 24h. The second dataset from Experiment002 contains data obtained from WT Bone marrow-derived macrophages treated with media or 5 mM itaconic acid for 16h.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Maxim N Artyomov  

PROVIDER: MSV000093522 | MassIVE | Tue Nov 28 12:29:00 GMT 2023

SECONDARY ACCESSION(S): PXD047348

REPOSITORIES: MassIVE