Transcriptomics

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Expression data from LSK WT and LSK NcstnKO


ABSTRACT: Notch signaling is one of the central regulators of differentiation in a variety of organisms and tissue types. Within the hematopoietic system, Notch is essential for the emergence of definitive HSC during fetal life and controls adult HSC differentiation to the T-cell lineage. Notch activation is controlled by the gamma-secretase complex complex, composed of presenilin, nicastrin (Ncstn), anterior pharynx-1 (Aph1), and presenilin enhancer-2 To determine other role of Notch signaling in HSC we designed a conditional mouse model of Nicastrin deletion. WT and KO HSC were analysed to determined genes controlled by Notch signaling.

ORGANISM(S): Mus musculus

PROVIDER: GSE27794 | GEO | 2011/05/12

SECONDARY ACCESSION(S): PRJNA141797

REPOSITORIES: GEO

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