Wild - type and PU.1 Q202L mutant mice ST - HSC (lin- c-kit+ Sca-1+ CD150- CD48-) and GMP (lin- c-kit+ Sca-1- CD16/32hi CD34+)
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ABSTRACT: Identification of differentially regulated genes in the PU.1 Q202L point mutant that disrupts association with c-Jun. The goal was to identify PU.1 target genes that depend on the co-activation of PU.1 by c-Jun. Mice have normal ST-HSC but lack normal GMP, so a population of GMP-like cells was used in the mutant.
ORGANISM(S): Mus musculus
PROVIDER: GSE27873 | GEO | 2016/03/07
SECONDARY ACCESSION(S): PRJNA138009
REPOSITORIES: GEO
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