IL-6-mediated activation of STAT3α prevents trauma/hemorrhagic shock-induced liver inflammation
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ABSTRACT: We previously demonstrated in rodents that T/HS results in liver injury that can be prevented by IL-6 administration at the start of resuscitation, however the mechanism(s) for the IL-6 protective effect is not fully known. We used microarrays to detail the global gene expression in response to T/HS and the effect of IL-6 on this model with and without pharmacologic blockade of Stat3-mediated IL-6 and identified distinct members of the inflammasome de-regulated during T/HS that normalized with IL-6 administration during resuscitation.
ORGANISM(S): Rattus norvegicus
PROVIDER: GSE27978 | GEO | 2011/03/16
SECONDARY ACCESSION(S): PRJNA137777
REPOSITORIES: GEO
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