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Oncogenic Transformation from Actinic Cheilosis to Squamous Cell Carcinoma of the Lip

ABSTRACT: Lip is an anatomical junction between skin and mucosa and the squamous cell carcinoma (SCC) is the most frequent lip cancers. Lip SCC is frequently developed from actinic cheilitis, presented as ulcerative lesions. However, changes in transcriptomes and tumor microenvironment driving oncogenic transformation from actinic cheilitis to lip SCC and determinants of differentiation of lip SCC are largely unknown. This study aimed to investigate differences between lip SCC and its premalignant actinic cheilitis and factors related to tumor differentiation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE280136 | GEO | 2024/10/28

REPOSITORIES: GEO

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Oncogenic Transformation from Actinic Cheilosis to Squamous Cell Carcinoma of the Lip

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