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Oncogenic Transformation from Actinic Cheilosis to Squamous Cell Carcinoma of the Lip

ABSTRACT: Oncogenic Transformation from Actinic Cheilosis to Squamous Cell Carcinoma of the Lip

PROVIDER: PRJNA1176521 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR31092000_1.fastq.gz	Fastqsanger.gz
	SRR31092000_2.fastq.gz	Fastqsanger.gz
	SRR31092001_1.fastq.gz	Fastqsanger.gz
	SRR31092001_2.fastq.gz	Fastqsanger.gz
	SRR31092002_1.fastq.gz	Fastqsanger.gz

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Oncogenic Transformation from Actinic Cheilosis to Squamous Cell Carcinoma of the Lip

Project description:Lip is an anatomical junction between skin and mucosa and the squamous cell carcinoma (SCC) is the most frequent lip cancers. Lip SCC is frequently developed from actinic cheilitis, presented as ulcerative lesions. However, changes in transcriptomes and tumor microenvironment driving oncogenic transformation from actinic cheilitis to lip SCC and determinants of differentiation of lip SCC are largely unknown. This study aimed to investigate differences between lip SCC and its premalignant actinic cheilitis and factors related to tumor differentiation.

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Project description:normal skin (no), actinic keratosis (ak), and squamous cell carcinoma (scc) of the skin were examined:; BACKGROUND: Carcinogenesis is a multi-step process indicated by several genes up- or down-regulated during tumor progression. This study examined and identified differentially expressed genes in cutaneous squamous cell carcinoma (SCC). RESULTS: Three different biopsies of 5 immunosuppressed organ-transplanted recipients each normal skin (all were pooled), actinic keratosis (AK) (two were pooled), and invasive SCC and additionally 5 normal skin tissues from immunocompetent patients were analyzed. Thus, total RNA of 15 specimens were used for hybridization with Affymetrix HG-U133A microarray technology containing 22,283 genes. Data analyses were performed by prediction analysis of microarrays using nearest shrunken centroids with the threshold 3.5 and ANOVA analysis was independently performed in order to identify differentially expressed genes (p < 0.05). Verification of 13 up- or down-regulated genes was performed by quantitative real-time reverse transcription (RT)-PCR and genes were additionally confirmed by sequencing. Broad coherent patterns in normal skin vs. AK and SCC were observed for 118 genes. CONCLUSION: The majority of identified differentially expressed genes in cutaneous SCC were previously not described.

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